产品货号：
Z11628
中文名称：
ASAH2抗体
英文名称：
Anti-ASAH2 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ASAH2 Antibody |
| 指标别名 | Acylsphingosine deacylase 2;ASAH2;hCD;HNAC1;LCDase;N CDase;NCDase;Neutral ceramidase;Non lysosomal ceramidase |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB |
| 基因名称 | ASAH2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | ASAH2 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human ASAH2.The immunogen is located within the last 50 amino acids of ASAH2. |
| 计算分子量 | 86kDa |
| 成分 | ASAH2 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | ASAH2 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids.These ceramidases are classified according to the pHrange that supports their optimal activity.ASAH2 is a neutral ceramidase and key regulator of sphingolipid signaling metabolites at the cell surface,catalyzing the hydrolysis of the N-acyl linkage of ceramide at an optimal pHof 6.5-8.5.ASAH2 is a type II integral membrane protein that can be cleaved to yield a soluble secreted protein and acts as a repressor of apoptosis both by reducing C16-ceramide,thereby preventing ceramide-induced apoptosis,and generating sphingosine.Sphingosine exerts both mitogenic and apoptosis-inducing activities,and its phosphorylated form functions as an intra- and intercellular second messenger.ASAH2 is ubiquitously expressed primarily expressed with higher levels in the intestine,kidney,skeletal muscle and heart.Recent studies indicate that ASAH2 encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the levels of bioactive sphingolipid metabolites in the intestinal tract. |
| Uniprot ID | Q9NR71 |
| 基因名全称 | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 |
| 蛋白名全称 | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 |
| 推荐稀释比 | ASAH2 antibody can be used for detection of ASAH2 by Western blot at 1 and 2μg/mL.Antibody validated:Western Blot in human samples.All other applications and species not yet tested. |
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